Yes, it is possible. It should not cause any issues especially if you prefer using a custom domain.
Here are benefits you will get with your custom domain:
- it looks attractive and secure;
- it generates a good impression to the users;
- a custom domain helps you to promote your brand or website;
- setting up a custom domain is quite easy;
Why it may be required to split the Campaigns between several domains?
Using multiple domains can sometimes be helpful if you promote multiple brands or different lines of products.
Another reason to use several domains - if you wish to buy traffic from specific Traffic Sources (Facebook, Google AdWords).
Google takes its policies serious. If your domain is considered unsafe, it may cause some issues with other Campaigns where this domain is also used. The best way to avoid possible issues is making sure your campaign complies with their rules and you use an uncompromised domain.
In short, maintaining multiple domains can help you to promote your Offers, receive maximum profit and escape some issues with blocking.